Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucagon | GNMT activity is induced by glucagon | Mus musculus | |
glucagon | GNMT activity is induced by glucagon | Homo sapiens | |
glucagon | GNMT activity is induced by glucagon | Sus scrofa | |
glucagon | GNMT activity is induced by glucagon | Oryctolagus cuniculus | |
glucagon | GNMT activity is induced by glucagon | Danio rerio | |
glucagon | GNMT activity is induced by glucagon | Rattus norvegicus | |
Vitamin A | GNMT activity is induced by vitamin A | Mus musculus | |
Vitamin A | GNMT activity is induced by vitamin A | Homo sapiens | |
Vitamin A | GNMT activity is induced by vitamin A | Sus scrofa | |
Vitamin A | GNMT activity is induced by vitamin A | Oryctolagus cuniculus | |
Vitamin A | GNMT activity is induced by vitamin A | Danio rerio | |
Vitamin A | GNMT activity is induced by vitamin A | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-Methyltetrahydrofolate pentaglutamate | - |
Danio rerio | |
5-Methyltetrahydrofolate pentaglutamate | - |
Homo sapiens | |
5-Methyltetrahydrofolate pentaglutamate | - |
Mus musculus | |
5-Methyltetrahydrofolate pentaglutamate | - |
Oryctolagus cuniculus | |
5-Methyltetrahydrofolate pentaglutamate | - |
Rattus norvegicus | |
5-Methyltetrahydrofolate pentaglutamate | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Sus scrofa | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
cytosol | - |
Danio rerio | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
nucleus | presence in liver nuclei | Mus musculus | 5634 | - |
nucleus | presence in liver nuclei | Homo sapiens | 5634 | - |
nucleus | presence in liver nuclei | Sus scrofa | 5634 | - |
nucleus | presence in liver nuclei | Oryctolagus cuniculus | 5634 | - |
nucleus | presence in liver nuclei | Danio rerio | 5634 | - |
nucleus | presence in liver nuclei | Rattus norvegicus | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32500 | - |
4 * 32500 | Mus musculus |
32500 | - |
4 * 32500 | Homo sapiens |
32500 | - |
4 * 32500 | Sus scrofa |
32500 | - |
4 * 32500 | Oryctolagus cuniculus |
32500 | - |
4 * 32500 | Danio rerio |
32500 | - |
4 * 32500 | Rattus norvegicus |
130000 | - |
- |
Mus musculus |
130000 | - |
- |
Homo sapiens |
130000 | - |
- |
Sus scrofa |
130000 | - |
- |
Oryctolagus cuniculus |
130000 | - |
- |
Danio rerio |
130000 | - |
- |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | P13255 | - |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellar Purkinje cell | - |
Mus musculus | - |
cerebellar Purkinje cell | - |
Homo sapiens | - |
cerebellar Purkinje cell | - |
Oryctolagus cuniculus | - |
cerebellar Purkinje cell | - |
Rattus norvegicus | - |
cerebral cortical neuron | - |
Mus musculus | - |
cerebral cortical neuron | - |
Homo sapiens | - |
cerebral cortical neuron | - |
Oryctolagus cuniculus | - |
cerebral cortical neuron | - |
Rattus norvegicus | - |
intestinal mucosa | - |
Mus musculus | - |
intestinal mucosa | - |
Homo sapiens | - |
intestinal mucosa | - |
Oryctolagus cuniculus | - |
intestinal mucosa | - |
Rattus norvegicus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Danio rerio | - |
liver | - |
Rattus norvegicus | - |
pancreas | - |
Mus musculus | - |
pancreas | - |
Homo sapiens | - |
pancreas | - |
Sus scrofa | - |
pancreas | - |
Oryctolagus cuniculus | - |
pancreas | - |
Rattus norvegicus | - |
prostate gland | - |
Mus musculus | - |
prostate gland | - |
Homo sapiens | - |
prostate gland | - |
Sus scrofa | - |
prostate gland | - |
Oryctolagus cuniculus | - |
prostate gland | - |
Rattus norvegicus | - |
renal proximal tubule | - |
Mus musculus | - |
renal proximal tubule | - |
Homo sapiens | - |
renal proximal tubule | - |
Oryctolagus cuniculus | - |
renal proximal tubule | - |
Rattus norvegicus | - |
submandibular gland | - |
Mus musculus | - |
submandibular gland | - |
Homo sapiens | - |
submandibular gland | - |
Oryctolagus cuniculus | - |
submandibular gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + glycine | - |
Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Sus scrofa | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Danio rerio | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 32500 | Mus musculus |
homotetramer | 4 * 32500 | Homo sapiens |
homotetramer | 4 * 32500 | Sus scrofa |
homotetramer | 4 * 32500 | Oryctolagus cuniculus |
homotetramer | 4 * 32500 | Danio rerio |
homotetramer | 4 * 32500 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
glycine methyltransferase | - |
Mus musculus |
glycine methyltransferase | - |
Homo sapiens |
glycine methyltransferase | - |
Sus scrofa |
glycine methyltransferase | - |
Oryctolagus cuniculus |
glycine methyltransferase | - |
Danio rerio |
glycine methyltransferase | - |
Rattus norvegicus |
GNMT | - |
Mus musculus |
GNMT | - |
Homo sapiens |
GNMT | - |
Sus scrofa |
GNMT | - |
Oryctolagus cuniculus |
GNMT | - |
Danio rerio |
GNMT | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Mus musculus |
9 | - |
- |
Homo sapiens |
9 | - |
- |
Sus scrofa |
9 | - |
- |
Oryctolagus cuniculus |
9 | - |
- |
Danio rerio |
9 | - |
- |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0013 | - |
native enzyme | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate | |
0.59 | - |
recombinant enzyme | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate |
Organism | Comment | Expression |
---|---|---|
Mus musculus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
Homo sapiens | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
Sus scrofa | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
Oryctolagus cuniculus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
Danio rerio | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
Rattus norvegicus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
General Information | Comment | Organism |
---|---|---|
malfunction | Gnmt knockout mice develop fatty livers when they have increased S-adenosyl-L-methionine | Mus musculus |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Mus musculus |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Homo sapiens |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Sus scrofa |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Oryctolagus cuniculus |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Danio rerio |
metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Rattus norvegicus |
physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Mus musculus |
physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Homo sapiens |
physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Sus scrofa |
physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Oryctolagus cuniculus |
physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Rattus norvegicus |