Literature summary for 2.1.1.20 extracted from

Beagle, B.; Yang, T.L.; Hung, J.; Cogger, E.A.; Moriarty, D.J.; Caudill, M.A.
The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake (2005), J. Nutr., 135, 2780-2785.

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Application

Application	Comment	Organism
medicine	GNMT 1289 C->T polymorphism influences plasma homocysteine and is responsive to folate intake, plasma homocysteine concentrations do not differ among the GNMT C1289T genotypes at baseline. After folate restriction, women with the GNMT 1289 TT genotype have higher homocysteine concentrations than women with the CT or CC genotype. The influence of the GNMT 1289 C->T variant on homocysteine is dependent on the MTHFR C677T genotype. In subjects with the MTHFR 677 CC genotype, homocysteine is greater for GNMT 1289 TT subjects relative to 1289 CT or CC subjects. In subjects with the MTHFR 677 TT genotype, plasma homocysteine concentrations do not differ among the GNMT C1289T genotypes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	women	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GNMT	-	Homo sapiens

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Release 2023.1 (January 2023)