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Literature summary for 2.1.1.20 extracted from

  • Huang, Y.C.; Lee, C.M.; Chen, M.; Chung, M.Y.; Chang, Y.H.; Huang, W.J.; Ho, D.M.; Pan, C.C.; Wu, T.T.; Yang, S.; Lin, M.W.; Hsieh, J.T.; Chen, Y.M.
    Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer (2007), Clin. Cancer Res., 13, 1412-1420.
    View publication on PubMed

Application

Application Comment Organism
diagnostics partially suitable to distinguish between benign and malign tumor forms Homo sapiens
medicine GNMT is a tumor susceptibility gene for prostate cancer, three major GNMT haplotypes in our populations, haplotype C conferred protection from the development of prostate cancer and exhibits the highest promoter activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
PC-3 cells, LNCaP cells, HA22T/VGH cells and HEK-293A cells transfected with plasmid containing haplotype C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene ?
-
?
S-adenosyl-L-methionine + glycine Homo sapiens key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
prostate cancer patients and normal control individuals
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
mononuclear cell DNA extracted from peripherial blood cells Homo sapiens
-
additional information abundant GNMT expression in benign prostatic hyperplasia tissue Homo sapiens
-
pancreas
-
Homo sapiens
-
prostate abundant GNMT expression Homo sapiens
-
prostate high GNMT-expression in normal prostatic and benign prostatic hyperplasia tissues, whereas it was diminished in 82% of the prostate cancer tissues Homo sapiens
-
prostate cancer cell 36.4% of tissues show loss of heterozygosity of the GNMT gene, GNMT expression diminished in 82.2% of tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene Homo sapiens ?
-
?
S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Synonyms

Synonyms Comment Organism
GNMT
-
Homo sapiens