Application | Comment | Organism |
---|---|---|
diagnostics | partially suitable to distinguish between benign and malign tumor forms | Homo sapiens |
medicine | GNMT is a tumor susceptibility gene for prostate cancer, three major GNMT haplotypes in our populations, haplotype C conferred protection from the development of prostate cancer and exhibits the highest promoter activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
PC-3 cells, LNCaP cells, HA22T/VGH cells and HEK-293A cells transfected with plasmid containing haplotype C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene | ? | - |
? | |
S-adenosyl-L-methionine + glycine | Homo sapiens | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
prostate cancer patients and normal control individuals | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
mononuclear cell | DNA extracted from peripherial blood cells | Homo sapiens | - |
additional information | abundant GNMT expression in benign prostatic hyperplasia tissue | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
prostate | abundant GNMT expression | Homo sapiens | - |
prostate | high GNMT-expression in normal prostatic and benign prostatic hyperplasia tissues, whereas it was diminished in 82% of the prostate cancer tissues | Homo sapiens | - |
prostate cancer cell | 36.4% of tissues show loss of heterozygosity of the GNMT gene, GNMT expression diminished in 82.2% of tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + glycine | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway | Homo sapiens | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Synonyms | Comment | Organism |
---|---|---|
GNMT | - |
Homo sapiens |