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Literature summary for 2.1.1.2 extracted from

  • Ide, T.; Brown-Endres, L.; Chu, K.; Ongusaha, P.P.; Ohtsuka, T.; El-Deiry, W.S.; Aaronson, S.A.; Lee, S.W.
    GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress (2009), Mol. Cell, 36, 379-392.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saos2, U2OS, and A-549 cells Mus musculus
expressed in Saos2, U2OS, and A-549 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
pancreas
-
 Mus musculus
-
pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanidinoacetate
-
 Mus musculus S-adenosyl-L-homocysteine + creatine
-
 ?
S-adenosyl-L-methionine + guanidinoacetate
-
 Homo sapiens S-adenosyl-L-homocysteine + creatine
-
 ?

Synonyms

Synonyms Comment Organism
GAMT
-
 Mus musculus
GAMT
-
 Homo sapiens
guanidinoacetate methyltransferase
-
 Mus musculus
guanidinoacetate methyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus GAMT induction in response to DNA damage is dependent upon p53, GAMT also shows p53-dependent induction in response to exogenously expressed p53 and genotoxic stress, metabolic stress induces GAMT expression to regulate creatine levels in a p53-dependent manner up
Homo sapiens GAMT induction in response to DNA damage is dependent upon p53, GAMT also shows p53-dependent induction in response to exogenously expressed p53 and genotoxic stress, metabolic stress induces GAMT expression to regulate creatine levels in a p53-dependent manner up

General Information

General Information Comment Organism
physiological function GAMT is not only involved in p53-dependent apoptosis in response to genotoxic stress but is important for apoptosis induced by glucose deprivation Mus musculus
physiological function GAMT is not only involved in p53-dependent apoptosis in response to genotoxic stress but is important for apoptosis induced by glucose deprivation Homo sapiens