Any feedback?
Literature summary for 2.1.1.2 extracted from
- AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review (2008), J. Inherit. Metab. Dis., 31, 230-239.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
| astrocyte | - |
Homo sapiens | - |
| brain | expressed within the brain, both during development and in adulthood | Mus musculus | - |
| brain | expressed within the brain, both during development and in adulthood | Homo sapiens | - |
| central nervous system | - |
Mus musculus | - |
| central nervous system | - |
Homo sapiens | - |
| cerebral gray matter | - |
Mus musculus | - |
| cerebral gray matter | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| additional information | not expressed in microcapillary endothelial cells | Mus musculus | - |
| additional information | not expressed in microcapillary endothelial cells | Homo sapiens | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| oligodendrocyte | - |
Mus musculus | - |
| oligodendrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? |  |
| S-adenosyl-L-methionine + guanidinoacetate | - |
Homo sapiens | S-adenosyl-L-homocysteine + creatine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAMT | - |
Mus musculus |
| GAMT | - |
Homo sapiens |
| guanidinoacetate methyltransferase | - |
Mus musculus |
| guanidinoacetate methyltransferase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | GAMT-cerebrospinal fluid knockout mice show decreased levels of creatine within their brain, which however still reach 1.4 mM or 0.4-0.5 mol/g of tissue, and a very significant increase in guanidinoacetate (1.9 mol/g tissue), GAMT knockout mice slowly replenish their brain creatine upon creatine treatment | Mus musculus |
| malfunction | GAMT-deficient patients have strongly decreased levels of creatine in cerebrospinal fluid but are able to import creatine from the blood | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
