Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CN- | - |
Cavia porcellus | |
CN- | - |
Sus scrofa | |
CN- | - |
Bos taurus | |
CN- | - |
Oryctolagus cuniculus | |
cysteine | - |
Cavia porcellus | |
cysteine | - |
Sus scrofa | |
cysteine | - |
Bos taurus | |
cysteine | - |
Oryctolagus cuniculus | |
glutathione | required for maximum activity, can be replaced by other reducing agents | Cavia porcellus | |
glutathione | required for maximum activity, can be replaced by other reducing agents | Sus scrofa | |
glutathione | required for maximum activity, can be replaced by other reducing agents | Bos taurus | |
glutathione | required for maximum activity, can be replaced by other reducing agents | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p-chloromercuribenzoate | complete inhibition at 1 mM, reversible by addition of glutathione | Bos taurus | |
p-chloromercuribenzoate | complete inhibition at 1 mM, reversible by addition of glutathione | Cavia porcellus | |
p-chloromercuribenzoate | complete inhibition at 1 mM, reversible by addition of glutathione | Oryctolagus cuniculus | |
p-chloromercuribenzoate | complete inhibition at 1 mM, reversible by addition of glutathione | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Cavia porcellus | |
Mg2+ | - |
Sus scrofa | |
Mg2+ | - |
Bos taurus | |
Mg2+ | - |
Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | Cavia porcellus | biosynthesis of creatine | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | Sus scrofa | biosynthesis of creatine | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | Bos taurus | biosynthesis of creatine | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | Oryctolagus cuniculus | biosynthesis of creatine | S-adenosyl-L-homocysteine + creatine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
muscle | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.022 | - |
purified enzyme | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | S-adenosyl-L-methionine is the only possible methyl donor | Cavia porcellus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | S-adenosyl-L-methionine is the only possible methyl donor | Sus scrofa | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | S-adenosyl-L-methionine is the only possible methyl donor | Bos taurus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | S-adenosyl-L-methionine is the only possible methyl donor | Oryctolagus cuniculus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | biosynthesis of creatine | Cavia porcellus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | biosynthesis of creatine | Sus scrofa | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | biosynthesis of creatine | Bos taurus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | biosynthesis of creatine | Oryctolagus cuniculus | S-adenosyl-L-homocysteine + creatine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Cavia porcellus |
7.5 | - |
- |
Sus scrofa |
7.5 | - |
- |
Bos taurus |
7.5 | - |
- |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Cavia porcellus | |
ATP | - |
Sus scrofa | |
ATP | - |
Bos taurus | |
ATP | - |
Oryctolagus cuniculus |