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Literature summary for 2.1.1.192 extracted from

  • LaMarre, J.M.; Howden, B.P.; Mankin, A.S.
    Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance (2011), Antimicrob. Agents Chemother., 55, 2989-2991.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.192

Cloned(Commentary)

Cloned (Comment) Organism
gene rlmN Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA Staphylococcus aureus
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 gene rlmN
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
RlmN
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction a naturally occurring rlmN mutation, by codon insertion in the rlmN gene, in a clinical Staphylococcus aureus isolate, strain JKD6229, decreases susceptibility to oxazolidinone antibiotic linezolid and is thought to increase the extent of A2503 modification, but mutation in fact abolishes RlmN activity, resulting in a lack of A2503 modification. rlmN knockout mutant Staphylococcus aureus Newman strain, SAV1218, shows a slight decrease in linezolid resistance, overview Staphylococcus aureus