Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptococcus pneumoniae | the enzyme also methylates uracil1939 in 23S rRNA | ? | - |
? | |
additional information | Streptococcus pneumoniae S1 | the enzyme also methylates uracil1939 in 23S rRNA | ? | - |
? | |
S-adenosyl-L-methionine + uracil747 in 23S rRNA | Streptococcus pneumoniae | - |
S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + uracil747 in 23S rRNA | Streptococcus pneumoniae S1 | - |
S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae S1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme also methylates uracil1939 in 23S rRNA | Streptococcus pneumoniae | ? | - |
? | |
additional information | the enzyme also methylates uracil1939 in 23S rRNA | Streptococcus pneumoniae S1 | ? | - |
? | |
S-adenosyl-L-methionine + uracil747 in 23S rRNA | - |
Streptococcus pneumoniae | S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + uracil747 in 23S rRNA | - |
Streptococcus pneumoniae S1 | S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RlmCD | - |
Streptococcus pneumoniae |
SP 1029 | - |
Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inactivation reduces N1-methylated level of G748 by RlmAII in vivo, leading to telithromycin resistance when the nucleotide A2058, located in domain V of 23S rRNA, is dimethylated by the dimethyltransferase Erm(B) | Streptococcus pneumoniae |
metabolism | methylation of uridine747 by the enzyme enhances adjacent guanine748 methylation by RlmAII leading to telithromycin-susceptibility | Streptococcus pneumoniae |