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Literature summary for 2.1.1.182 extracted from

  • Kyuma, T.; Kizaki, H.; Ryuno, H.; Sekimizu, K.; Kaito, C.
    16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus (2015), Biochimie, 119, 166-174.
    View publication on PubMed
Search for more literature for 2.1.1.182

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Staphylococcus aureus
-
 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Staphylococcus aureus RN4220
-
 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Staphylococcus aureus RN4220 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
KsgA
-
 Staphylococcus aureus
RsmA
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction the enzyme knockout strain is sensitive to oxidative stress and has a lower survival rate in murine macrophage RAW264.7 cells than the parent strain Staphylococcus aureus
physiological function the enzyme contributes to maintain ribosome function under oxidative conditions and thus to Staphylococcus aureus virulence Staphylococcus aureus