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Literature summary for 2.1.1.179 extracted from

  • Lioy, V.S.; Goussard, S.; Guerineau, V.; Yoon, E.J.; Courvalin, P.; Galimand, M.; Grillot-Courvalin, C.
    Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host (2014), RNA, 20, 382-391.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
16S rRNA methyltransferase ArmA
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli
-
S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli BW25113
-
S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli MM294
-
S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli MM294
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
Escherichia coli BW25113 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
Escherichia coli MM294 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
?

Synonyms

Synonyms Comment Organism
G1405 methyltransferase ArmA
-
Escherichia coli