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Literature summary for 2.1.1.179 extracted from

  • Galimand, M.; Courvalin, P.; Lambert, T.
    RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family (2012), Antimicrob. Agents Chemother., 56, 3960-3962.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.179

Cloned(Commentary)

Cloned (Comment) Organism
gene rmtF encoded on a non-self-transferable plasmid pIP849, cotranscribed with the upstream aac(6')-Ib gene, DNA and amino acid sequence determination, analysis, and comparisons, overview. Genetic structure and phylogenetic tree Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Klebsiella pneumoniae
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + cytosine1405 in 16S rRNA Klebsiella pneumoniae BM4686
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae I1YZZ5
-
-
Klebsiella pneumoniae I1YZZ5 gene rmtF encoded on a non-self-transferable plasmid pIP849
-
Klebsiella pneumoniae BM4686 I1YZZ5 gene rmtF encoded on a non-self-transferable plasmid pIP849
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Klebsiella pneumoniae S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + cytosine1405 in 16S rRNA
-
 Klebsiella pneumoniae BM4686 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
16S rRNA N7 G1405 methyltransferase
-
 Klebsiella pneumoniae
RmtF
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 Klebsiella pneumoniae
RmtF RmtF protein has 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Klebsiella pneumoniae

General Information

General Information Comment Organism
evolution RmtF is a member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family Klebsiella pneumoniae
physiological function methylation of C1405, involved in the binding of aminoglycosides to 16S rRNA, can lead to loss of affinity and to resistance of the host. Resistance conferred by RmtF cannot be transferred to Escherichia coli via transfer of plasmid pIP849 Klebsiella pneumoniae