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Literature summary for 2.1.1.179 extracted from

  • Savic, M.; Lovric, J.; Tomic, T.I.; Vasiljevic, B.; Conn, G.L.
    Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics (2009), Nucleic Acids Res., 37, 5420-5431.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.179

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Micromonospora echinospora the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Frankia sp. the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Micromonospora zionensis the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Frankia sp. CcI3 the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Frankia sp. Q2J7L5 strain Ccl3
-
Frankia sp. CcI3 Q2J7L5 strain Ccl3
-
Micromonospora echinospora Q70KC8
-
-
Micromonospora zionensis Q7M0R2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Frankia sp. S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Frankia sp. S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as guanine1405 by MALDI-ToF mass spectrometry Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Frankia sp. CcI3 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Frankia sp. CcI3 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
GrmA
-
 Micromonospora echinospora
Krm
-
 Frankia sp.
sgm
-
 Micromonospora zionensis
sisomicin-gentamicin methylase
-
 Micromonospora zionensis

General Information

General Information Comment Organism
physiological function the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Micromonospora zionensis