Literature summary for 2.1.1.17 extracted from

Shields, D.J.; Lingrell, S.; Agellon, L.B.; Brosnan, J.T.; Vance, D.E.
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase (2005), J. Biol. Chem., 280, 27339-27344.

Search for more literature for 2.1.1.17

Protein Variants

Protein Variants	Comment	Organism
H196S	protein is barely detectable due to poor expression or rapid degradation	Mus musculus
K197S	fails to localize to endoplasmic reticulum, but localize to Golgi apparatus, mutant is catalytically active	Mus musculus
K197S/R198S	fails to localize to endoplasmic reticulum, but localize to Golgi apparatus, mutant is catalytically active	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Mus musculus	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization	Mus musculus	?	-	?

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Release 2023.1 (January 2023)