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Literature summary for 2.1.1.166 extracted from
- Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation (2019), Nucleic Acids Res., 47, 4226-4239 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli BW25113 | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RlmE | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in an Escherichia coli strain lacking SAH nucleosidase Mtn, in which cellular SAM is down-regulated, hypomodification of several methylation sites is observed, including 2'-O-methylation at position 2552 (Um2552) of 23S rRNA. There is a severe growth defect of the strain with significant accumulation of 45S ribosomal precursor harboring 23S rRNA with hypomodified Um2552. The growth defect is partially restored by overexpression of SAM-dependent methyltransferase RlmE | Escherichia coli |
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Release 2023.1 (January 2023)
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