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Literature summary for 2.1.1.159 extracted from

  • Mizuno, K.; Kurosawa, S.; Yoshizawa, Y.; Kato, M.
    Essential region for 3-N methylation in N-methyltransferases involved in caffeine biosynthesis (2010), Z. Naturforsch. C, 65c, 257-265.
    View publication on PubMed
Search for more literature for 2.1.1.159

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in Escherichia coli strain BL21 (DE3), sequence comparisonof caffeine synthetic enzymes from coffee Coffea sp.

Protein Variants

Protein Variants Comment Organism
additional information construction of several enzyme mutants, overview Coffea sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 7-methylxanthine Coffea sp.
-
 S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
 ?

Organism

Organism UniProt Comment Textmining
Coffea sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information minor activity of 3-N-methylation of paraxanthine is present in theobromine synthase Coffea sp. ?
-
 ?
S-adenosyl-L-methionine + 7-methylxanthine
-
 Coffea sp. S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
-
 ?

Synonyms

Synonyms Comment Organism
3-N-methyltransferase
-
 Coffea sp.
CTS1
-
 Coffea sp.
CTS2
-
 Coffea sp.

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Coffea sp.

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the second step in caffeine biosynthesis, pathway overview Coffea sp.