Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.148 extracted from

  • Luciani, R.; Saxena, P.; Surade, S.; Santucci, M.; Venturelli, A.; Borsari, C.; Marverti, G.; Ponterini, G.; Ferrari, S.; Blundell, T.L.; Costi, M.P.
    Virtual screening and X-ray crystallography identify non-substrate analog inhibitors of flavin-dependent thymidylate synthase (2016), J. Med. Chem., 59, 9269-9275 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of ThyX in complex with nonsubstrate analog inhibitor (2R)-2-[(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid Thermotoga maritima

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-[(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid 6% inhibition at 0.1 mM Thermotoga maritima

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
dUMP pH not specified in the publication, temperature not specified in the publication Thermotoga maritima
0.13
-
NADPH pH not specified in the publication, temperature not specified in the publication Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9WYT0
-
-
Thermotoga maritima DSM 3109 Q9WYT0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + NADPH + H+
-
Thermotoga maritima dTMP + tetrahydrofolate + NADP+
-
?
5,10-methylenetetrahydrofolate + dUMP + NADPH + H+
-
Thermotoga maritima DSM 3109 dTMP + tetrahydrofolate + NADP+
-
?

Synonyms

Synonyms Comment Organism
ThyX
-
Thermotoga maritima