Literature summary for 2.1.1.148 extracted from

Mishanina, T.V.; Corcoran, J.M.; Kohen, A.
Substrate activation in flavin-dependent thymidylate synthase (2014), J. Am. Chem. Soc., 136, 10597-10600.

Search for more literature for 2.1.1.148

Organism

Organism	UniProt	Comment	Textmining
Thermotoga maritima	Q9WYT0	-	-
Thermotoga maritima ATCC 43589	Q9WYT0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	an initial activation of the pyrimidine substrate by reduced flavin is required for catalysis. A H/D exchange at C5 of dUMP in D2O requires the flavin to be reduced, as observed experimentally. Chemical trapping of reaction intermediates shows the unusual intermediates of further steps	Thermotoga maritima	?	-	?
additional information	an initial activation of the pyrimidine substrate by reduced flavin is required for catalysis. A H/D exchange at C5 of dUMP in D2O requires the flavin to be reduced, as observed experimentally. Chemical trapping of reaction intermediates shows the unusual intermediates of further steps	Thermotoga maritima ATCC 43589	?	-	?

Synonyms

Synonyms	Comment	Organism
FDTS	-	Thermotoga maritima
flavin-dependent thymidylate synthase	-	Thermotoga maritima

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)