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Literature summary for 2.1.1.148 extracted from

  • Wang, Z.; Chernyshev, A.; Koehn, E.M.; Manuel, T.D.; Lesley, S.A.; Kohen, A.
    Oxidase activity of a flavin-dependent thymidylate synthase (2009), FEBS J., 276, 2801-2810.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
tetrahydrofolate competitively inhibits the oxidase activity of the enzyme, which indicates that tetrahydrofolate and O2 compete for the same reduced and dUMP-activated enzymatic complex Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9WYT0 enzyme additionally shows oxidase activity
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information flavin-dependent thymidylate synthase can function as an oxidase, which catalyzes the reduction of O2 to H2O2, using reduced NADPH or other reducing agents and a sequential kinetic mechanism of substrate binding. Tetrahydrofolate competitively inhibits the oxidase activity, which indicates that tetrahydrofolate and O2 compete for the same reduced and dUMP-activated enzymatic complex Thermotoga maritima ?
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