Application | Comment | Organism |
---|---|---|
additional information | residues His53, Glu190, Arg90, and Arg182 are essential for TS activity | Paramecium bursaria Chlorella virus-1 |
Crystallization (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
crystal structure shows certain small structural differences in the active site when compared with either bacterial FDTS | Paramecium bursaria Chlorella virus-1 |
crystal structure shows no structural similarity with classical TS | Thermotoga maritima |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 5-fluorouracil is not a potential inhibitor | Paramecium bursaria Chlorella virus-1 | |
NADPH | inhibits FDTS at high concentrations at all temperatures, NADPH may not be the natural reducing agent of FDTS | Thermotoga maritima |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Chlamydia trachomatis | - |
- |
- |
Clostridium botulinum | - |
- |
- |
Helicobacter pylori | - |
- |
- |
Mycobacterium leprae | - |
- |
- |
Mycobacterium tuberculosis | P9WG57 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WG57 | - |
- |
no activity in Homo sapiens | - |
- |
- |
Paramecium bursaria Chlorella virus-1 | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Rickettsia sp. | - |
- |
- |
Thermotoga maritima | - |
- |
- |
Treponema palladium | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia trachomatis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Helicobacter pylori | dTMP + tetrahydrofolate + FAD | - |
? | |
additional information | mRNA binding traits | Pyrococcus furiosus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Thermotoga maritima |
Synonyms | Comment | Organism |
---|---|---|
FDTS | - |
Chlamydia trachomatis |
FDTS | - |
Pyrococcus furiosus |
FDTS | - |
Mycobacterium leprae |
FDTS | - |
Helicobacter pylori |
FDTS | - |
Thermotoga maritima |
FDTS | - |
Clostridium botulinum |
FDTS | - |
Rickettsia sp. |
FDTS | - |
Bacillus anthracis |
FDTS | - |
Paramecium bursaria Chlorella virus-1 |
FDTS | - |
Treponema palladium |
FDTS | - |
Mycobacterium tuberculosis |
flavin-dependent thymidylate synthase | - |
Chlamydia trachomatis |
flavin-dependent thymidylate synthase | - |
Pyrococcus furiosus |
flavin-dependent thymidylate synthase | - |
Mycobacterium leprae |
flavin-dependent thymidylate synthase | - |
Helicobacter pylori |
flavin-dependent thymidylate synthase | - |
Thermotoga maritima |
flavin-dependent thymidylate synthase | - |
Clostridium botulinum |
flavin-dependent thymidylate synthase | - |
Rickettsia sp. |
flavin-dependent thymidylate synthase | - |
Bacillus anthracis |
flavin-dependent thymidylate synthase | - |
Paramecium bursaria Chlorella virus-1 |
flavin-dependent thymidylate synthase | - |
Treponema palladium |
flavin-dependent thymidylate synthase | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Helicobacter pylori | |
NADH | - |
Helicobacter pylori |