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Literature summary for 2.1.1.143 extracted from
- The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products (2010), Plant Physiol., 153, 741-756.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 24-methylenelophenol | Arabidopsis thaliana | - |
S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 24-methylenelophenol | - |
Arabidopsis thaliana | S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C-24 SMT | - |
Arabidopsis thaliana |
| SMT2 | - |
Arabidopsis thaliana |
| sterol methyltransferase | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | SMT2 and SMT3 genes are highly homologous and encode highly similar sterol 24-carbon methyltransferases | Arabidopsis thaliana |
| malfunction | deficiency of SMT2 in the cvp1 mutant results in moderate developmental defects, including aberrant cotyledon vein patterning, serrated floral organs, and reduced stature, but plants are viable, suggesting that SMT3 activity can substitute for the loss of SMT2, overview. Mutation in both SMT2 and SMT3 causes extreme alteration in sterol composition, sterol profiles of smt mutants, overview. Mutants deficient in both SMT1 and SMT2 are embryo lethal. Phenotypes, detailed overview | Arabidopsis thaliana |
| metabolism | SMT2 and SMT3 are involved in the phytosterol biosynthetic pathway, overview | Arabidopsis thaliana |
| physiological function | gene SMT2 encodes a C-24 SMT, that catalyzes the reaction that distinguishes the synthesis of structural sterols from signaling brassinosteroid derivatives and is highly regulated. Distinct developmental roles of SMT2 and SMT3, SMT3, which also encodes a C-24 SMT, overview | Arabidopsis thaliana |
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