Literature summary for 2.1.1.14 extracted from

Romek, K.M.; Krzeminska, A.; Remaud, G.S.; Julien, M.; Paneth, P.; Robins, R.J.
Insights into the role of methionine synthase in the universal 13C depletion in O- and N-methyl groups of natural products (2017), Arch. Biochem. Biophys., 635, 60-65 .

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Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

General Information

General Information	Comment	Organism
physiological function	within L-methionine of natural origin, the S-methyl group is depleted in 13C by about 2% relative to the other positions in the molecule. Calculation predicts a strong normal 13C kinetic isotope effect (1.087) associated with methionine synthase. Depletion in 13C in the S-methyl of L-methionine during biosynthesis is an important factor contributing to the general depletion seen in many O-methyl and N-methyl groups of natural products	synthetic construct

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Release 2023.1 (January 2023)