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Literature summary for 2.1.1.137 extracted from

  • Sumi, D.; Himeno, S.
    Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity (2012), Biol. Pharm. Bull., 35, 1870-1875.
    View publication on PubMed
Search for more literature for 2.1.1.137

Protein Variants

Protein Variants Comment Organism
M287T the substitution results in an increase in the capacity of the first step of methylation, leading to an increase in the percentage of urinary methylarsonate, but not the second step of methylation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41700
-
 x * 41700, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens
-
 S-adenosyl-L-homocysteine + methylarsonate
-
 ?
S-adenosyl-L-methionine + methylarsonite Homo sapiens
-
 S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBK9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
S-adenosyl-L-methionine + methylarsonite
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Subunits

Subunits Comment Organism
? x * 41700, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
arsenic (+3 oxidation state) methyltransferase
-
 Homo sapiens
arsenite (+3 oxidation state) methyltransferase
-
 Homo sapiens
AS3MT
-
 Homo sapiens