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Literature summary for 2.1.1.137 extracted from
- Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes (2008), Environ. Health Perspect., 116, 501-505.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genotyping | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| M287T | naturally occuring mutant | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | As3MT methylates inorganic arsenic and its metabolites | ? | - |
? |  |
| S-adenosyl-L-methionine + arsenite | Homo sapiens | As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9HBK9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | As3MT methylates inorganic arsenic and its metabolites | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
| S-adenosyl-L-methionine + arsenite | As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview | Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arsenic (+3) methyltransferase | - |
Homo sapiens |
| AS3MT | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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