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Literature summary for 2.1.1.137 extracted from
- A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19 (2005), Arch. Toxicol., 79, 183-191.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | nonenzymatic generation of arsenic triglutathione from arsenite when GSH is present at concentrations 2 mM or higher. Methylation of arsenic is catalyzed by Cyt19 only when arsenic triglutathione is present in the reaction mixture | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | monomethylarsonous acid is not methylated | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
| S-adenosyl-L-methionine + methylarsonite | - |
Homo sapiens | S-adenosyl-L-homocysteine + dimethylarsinate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arsenic methyltransferase Cyt19 | - |
Homo sapiens |
| Cyt19 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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