KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Escherichia coli | |
0.0016 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
0.016 | - |
L-homocysteine | - |
Escherichia coli | |
0.03 | - |
5-methyltetrahydrofolate | - |
Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
140000 | 150000 | gel filtration, sedimentation coefficient in sucrose density gradients | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Auxenochlorella pyrenoidosa | - |
- |
- |
Bos taurus | - |
- |
- |
Cereibacter sphaeroides | - |
- |
- |
Escherichia coli | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Klebsiella aerogenes | - |
- |
- |
Ochromonas malhamensis | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
B | Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Salmonella enterica subsp. enterica serovar Typhimurium | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Gallus gallus | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Escherichia coli | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Homo sapiens | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Rattus norvegicus | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Sus scrofa | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Bos taurus | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Cereibacter sphaeroides | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Klebsiella aerogenes | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Auxenochlorella pyrenoidosa | |
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Ochromonas malhamensis |
Renatured (Comment) | Organism |
---|---|
incubation of resolved apoenzyme with methyl-B12 results in spontaneous formation of holoenzyme | Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Bos taurus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Bos taurus | - |
liver | - |
Gallus gallus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
tissue culture | - |
Homo sapiens | - |
tissue culture | a variety of mammalian cell lines in tissue culture | Rattus norvegicus | - |
tissue culture | a variety of mammalian cell lines in tissue culture | Sus scrofa | - |
tissue culture | a variety of mammalian cell lines in tissue culture | Bos taurus | - |
tissue culture | a variety of mammalian cell lines in tissue culture | Auxenochlorella pyrenoidosa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
additional information | - |
- |
Gallus gallus |
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Bos taurus |
additional information | - |
- |
Cereibacter sphaeroides |
additional information | - |
- |
Klebsiella aerogenes |
additional information | - |
- |
Auxenochlorella pyrenoidosa |
additional information | - |
- |
Ochromonas malhamensis |
additional information | - |
assay method | Escherichia coli |
additional information | - |
assay method | Homo sapiens |
additional information | - |
assay method | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-methyltetrahydrofolate + 2-mercaptoethanol | - |
Escherichia coli | S-methylmercaptoethanol + tetrahydrofolate | - |
? | |
5-methyltetrahydrofolate + L-homocysteine | - |
Escherichia coli | tetrahydrofolate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Gallus gallus | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Escherichia coli | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Homo sapiens | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Rattus norvegicus | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Sus scrofa | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Bos taurus | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Cereibacter sphaeroides | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Klebsiella aerogenes | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Auxenochlorella pyrenoidosa | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine | - |
Ochromonas malhamensis | tetrahydropteroylmonoglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Gallus gallus | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Escherichia coli | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Homo sapiens | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Rattus norvegicus | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Sus scrofa | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Bos taurus | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Cereibacter sphaeroides | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Klebsiella aerogenes | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Auxenochlorella pyrenoidosa | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
N5-methyltetrahydropteroyltriglutamate + L-homocysteine | - |
Ochromonas malhamensis | tetrahydropteroyltriglutamate + L-methionine | - |
? | |
S-adenosyl-L-methionine + L-homocysteine | - |
Escherichia coli | methionine + S-adenosyl-L-homocysteine | - |
? | |
S-adenosyl-L-methionine + tetrahydrofolate | - |
Escherichia coli | 5-methyltetrahydrofolate + S-adenosyl-L-homocysteine | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0217 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
0.0367 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
8.33 | 13 | 5-methyltetrahydrofolate | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | absolute requirement for a reducing system | Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | absolute requirement for a reducing system | Gallus gallus | |
additional information | absolute requirement for a reducing system | Escherichia coli | |
additional information | absolute requirement for a reducing system | Homo sapiens | |
additional information | absolute requirement for a reducing system | Rattus norvegicus | |
additional information | absolute requirement for a reducing system | Sus scrofa | |
additional information | absolute requirement for a reducing system | Bos taurus | |
additional information | absolute requirement for a reducing system | Cereibacter sphaeroides | |
additional information | absolute requirement for a reducing system | Klebsiella aerogenes | |
additional information | absolute requirement for a reducing system | Auxenochlorella pyrenoidosa | |
additional information | absolute requirement for a reducing system | Ochromonas malhamensis | |
S-adenosyl-L-methionine | required | Salmonella enterica subsp. enterica serovar Typhimurium | |
S-adenosyl-L-methionine | required | Gallus gallus | |
S-adenosyl-L-methionine | required | Escherichia coli | |
S-adenosyl-L-methionine | required | Homo sapiens | |
S-adenosyl-L-methionine | required | Rattus norvegicus | |
S-adenosyl-L-methionine | required | Sus scrofa | |
S-adenosyl-L-methionine | required | Bos taurus | |
S-adenosyl-L-methionine | required | Cereibacter sphaeroides | |
S-adenosyl-L-methionine | required | Klebsiella aerogenes | |
S-adenosyl-L-methionine | required | Auxenochlorella pyrenoidosa | |
S-adenosyl-L-methionine | required | Ochromonas malhamensis | |
S-adenosyl-L-methionine | role of S-adenosyl-L-methionine | Escherichia coli | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Salmonella enterica subsp. enterica serovar Typhimurium | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Gallus gallus | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Escherichia coli | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Homo sapiens | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Rattus norvegicus | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Sus scrofa | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Bos taurus | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Cereibacter sphaeroides | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Klebsiella aerogenes | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Auxenochlorella pyrenoidosa | |
vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Ochromonas malhamensis |