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Literature summary for 2.1.1.13 extracted from
- On the cation sensibility of the vitamin B12-dependent methionine synthetase (5-methyltetrahydrofolate-homocysteine-methyltransferase from Escherichia coli) (1973), FEBS Lett., 35, 295-298.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| K+ | at 67 mM 1.4 fold activity | Escherichia coli |  |
| Li+ | at 67 mM, 1.3fold activity | Escherichia coli | |
| Na+ | at 67 mM 1.5 fold activity | Escherichia coli | |
| NH4+ | at 67 mM 1.5 fold activity | Escherichia coli | |
| S-adenosylmethionine | at about 0.0001 mM | Escherichia coli | |
| TrisHCl | at 67 mM 1.2 fold activity | Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activates | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N5-methyltetrahydrofolate + L-homocysteine | - |
Escherichia coli | tetrahydrofolate + L-methionine | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Escherichia coli | |
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