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Literature summary for 2.1.1.128 extracted from

  • Sato, F.; Tsujita, T.; Katagiri, Y.; Yoshida, S.; Yamada, Y.
    Purification and characterization of S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells (1994), Eur. J. Biochem., 225, 125-131.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizium 10 mM, 50% inhibition Coptis japonica
Co2+ 5 mM, severe inhibition Coptis japonica
Cu2+ 5 mM, severe inhibition Coptis japonica
Fe2+ 5 mM, severe inhibition Coptis japonica
Mn2+ 5 mM, severe inhibition Coptis japonica
Ni2+ 5 mM, severe inhibition Coptis japonica
S-adenosyl-L-homocysteine
-
Coptis japonica
Zn2+ 5 mM, severe inhibition Coptis japonica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.23
-
(R,S)-norlaudanosoline
-
Coptis japonica
3.95
-
S-adenosyl-L-methionine
-
Coptis japonica

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, SDS-PAGE Coptis japonica
95000
-
gel filtration Coptis japonica

Organism

Organism UniProt Comment Textmining
Coptis japonica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Coptis japonica

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine bi-bi ping-pong mechanism Coptis japonica

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Coptis japonica
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Coptis japonica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-Adenosyl-L-methionine + (R)-norlaudanosoline
-
Coptis japonica S-Adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline
-
?
S-adenosyl-L-methionine + (R,S)-norlaudanosoline
-
Coptis japonica S-adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline
-
?
S-adenosyl-L-methionine + (S)-norlaudanosoline activity with (R,S)-norlaudanosoline is 76% of the activity with (S)-norcoclaurine Coptis japonica S-adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline
-
?
S-Adenosyl-L-methionine + norcoclaurine (S)-norcoclaurine and (R)-norcoclaurine Coptis japonica S-Adenosyl-L-homocysteine + ?
-
?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Coptis japonica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Coptis japonica

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 about 50% of maximal activity at pH 7.0 and 9.5 Coptis japonica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
10
-
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizium
-
Coptis japonica