Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizium | 10 mM, 50% inhibition | Coptis japonica | |
Co2+ | 5 mM, severe inhibition | Coptis japonica | |
Cu2+ | 5 mM, severe inhibition | Coptis japonica | |
Fe2+ | 5 mM, severe inhibition | Coptis japonica | |
Mn2+ | 5 mM, severe inhibition | Coptis japonica | |
Ni2+ | 5 mM, severe inhibition | Coptis japonica | |
S-adenosyl-L-homocysteine | - |
Coptis japonica | |
Zn2+ | 5 mM, severe inhibition | Coptis japonica |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.23 | - |
(R,S)-norlaudanosoline | - |
Coptis japonica | |
3.95 | - |
S-adenosyl-L-methionine | - |
Coptis japonica |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
x * 40000, SDS-PAGE | Coptis japonica |
95000 | - |
gel filtration | Coptis japonica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coptis japonica | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Coptis japonica |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine | bi-bi ping-pong mechanism | Coptis japonica |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Coptis japonica | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Coptis japonica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-Adenosyl-L-methionine + (R)-norlaudanosoline | - |
Coptis japonica | S-Adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline | - |
? | |
S-adenosyl-L-methionine + (R,S)-norlaudanosoline | - |
Coptis japonica | S-adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline | - |
? | |
S-adenosyl-L-methionine + (S)-norlaudanosoline | activity with (R,S)-norlaudanosoline is 76% of the activity with (S)-norcoclaurine | Coptis japonica | S-adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline + 7-O-methylnorlaudanosoline | - |
? | |
S-Adenosyl-L-methionine + norcoclaurine | (S)-norcoclaurine and (R)-norcoclaurine | Coptis japonica | S-Adenosyl-L-homocysteine + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, SDS-PAGE | Coptis japonica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Coptis japonica |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9.5 | about 50% of maximal activity at pH 7.0 and 9.5 | Coptis japonica |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
10 | - |
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizium | - |
Coptis japonica |