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Literature summary for 2.1.1.113 extracted from

  • Li, S.; Cai, J.; Lu, H.; Mao, S.; Dai, S.; Hu, J.; Wang, L.; Hua, X.; Xu, H.; Tian, B.; Zhao, Y.; Hua, Y.
    N4-Cytosine DNA methylation is involved in the maintenance of genomic stability in Deinococcus radiodurans (2019), Front. Microbiol., 10, 1905 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Deinococcus radiodurans
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Deinococcus radiodurans R1
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Synonyms

Synonyms Comment Organism
DraR1
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 Deinococcus radiodurans
ORF16000P
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 Deinococcus radiodurans

General Information

General Information Comment Organism
physiological function enzyme recognizes the motif CCGCGG and methylates the second cytosine residue to give C4mCGCGG. N4-cytosine is the major methylated form in Deinococcus radiodurans. Cells deficient in 4mC modification display higher spontaneous rifampin mutation frequency and enhanced DNA recombination and transformation efficiency. Genes involved in the maintenance of genomic stability are differentially expressed in DraR1 mutant strains Deinococcus radiodurans