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Literature summary for 2.1.1.107 extracted from

  • Sattler, I.; Roessner, C.A.; Stolowich, N.J.; Hardin, S.H.; Harris-Haller, L.W.; Yokubaitis, N.T.; Murooka, Y.; Hashimoto, Y.; Scott, A.I.
    Cloning, sequencing, and expression of the uroporphyrinogen III methyltransferease cobA gene of Propionibacterium freudenreichii (shermanii) (1995), J. Bacteriol., 177, 1564-1569.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
overexpression of cobA gene in Escherichia coli TB1 Propionibacterium freudenreichii

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Propionibacterium freudenreichii
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 SDS-PAGE Propionibacterium freudenreichii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + uroporphyrinogen III Propionibacterium freudenreichii involved in biosynthesis of sirohydrochlorin 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ product is precorrin-2 ?
2 S-adenosyl-L-methionine + uroporphyrinogen III Propionibacterium freudenreichii involved in biosynthesis of cobalamin 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ product is precorrin-2 ?

Organism

Organism UniProt Comment Textmining
Propionibacterium freudenreichii Q51720
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + uroporphyrinogen III
-
 Propionibacterium freudenreichii 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ after prolonged incubation (15 h) also tri- and tetra-methylated compounds formed, third methyl group at position 12 ?
2 S-adenosyl-L-methionine + uroporphyrinogen III
-
 Propionibacterium freudenreichii 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ product is precorrin-2 ?
2 S-adenosyl-L-methionine + uroporphyrinogen III involved in biosynthesis of sirohydrochlorin Propionibacterium freudenreichii 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ product is precorrin-2 ?
2 S-adenosyl-L-methionine + uroporphyrinogen III involved in biosynthesis of cobalamin Propionibacterium freudenreichii 2 S-adenosyl-L-homocysteine + dihydrosirohydrochlorin + 2 H+ product is precorrin-2 ?
S-adenosyl-L-methionine + uroporphyrinogen I methylates positions 2 and 7 Propionibacterium freudenreichii ?
-
 ?