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Literature summary for 2.1.1.103 extracted from

  • Witola, W.H.; Cooks-Fagbodun, S.; Ordonez, A.R.; Matthews, K.; Abugri, D.A.; McHugh, M.
    Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus (2016), Vet. Parasitol., 223, 1-6 .
    View publication on PubMed
Search for more literature for 2.1.1.103

Inhibitors

Inhibitors Comment Organism Structure
7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione i.e. NSC-668394 Haemonchus contortus
NSC-641296 compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM); compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM) Haemonchus contortus

Organism

Organism UniProt Comment Textmining
Haemonchus contortus A0A2Z1FIB9
-
-
Haemonchus contortus U5HK48
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine Haemonchus contortus ?
-
-
additional information isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step Haemonchus contortus ?
-
-
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
-
 Haemonchus contortus choline phosphate + S-adenosyl-L-homocysteine
-
 ?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
-
 Haemonchus contortus N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
 ?
S-adenosyl-L-methionine + ethanolamine phosphate
-
 Haemonchus contortus S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PMT1
-
 Haemonchus contortus
PMT2
-
 Haemonchus contortus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0028
-
 combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication Haemonchus contortus 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
0.0051
-
 combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication Haemonchus contortus NSC-641296
0.0059
-
 isoform PMT1 alone, 24°C, pH not specified in the publication Haemonchus contortus 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
0.0083
-
 isoform PMT1 alone, 24°C, pH not specified in the publication Haemonchus contortus NSC-641296