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Literature summary for 2.1.1.100 extracted from
- Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing? (2013), Front. Aging Neurosci., 5, 40.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Icmt | - |
Mus musculus |
| isoprenylcysteine carboxyl methyltransferase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | reduced enzyme activity does not affect levels of prelamin A, but instead causes mislocalization of prelamin A away fromthe nuclear rim and triggers prelamin A-dependent activation of AKT-mTOR, which decreases premature senescence of zinc metallopeptidase STE24-deficient fibroblasts | Mus musculus |
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Release 2023.1 (January 2023)
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