Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-(acetylamino)-3-[[(2Z)-3,4-diphenylbut-2-en-1-yl]sulfanyl]propanoic acid | 15.7% inhibition at 0.01 mM | Homo sapiens | |
(2R)-2-(acetylamino)-3-[[(2Z)-4-(2-fluorophenyl)-3-phenylbut-2-en-1-yl]sulfanyl]propanoic acid | 25.3% inhibition at 0.01 mM | Homo sapiens | |
N-(2-phenoxybenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | 35.9% inhibition at 0.01 mM | Homo sapiens | |
N-(5-methoxy-2-nitrobenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | 10.1% inhibition at 0.01 mM | Homo sapiens | |
N-(biphenyl-2-ylcarbonyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | 17% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | 19.5% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-farnesyl-L-cysteine | complete inhibition at 0.025 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-4-(4-phenoxyphenoxy)but-2-en-1-yl]-L-cysteine | 15.5% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-4-[(naphthalen-2-ylamino)oxy]but-2-en-1-yl]-L-cysteine | 14.5% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-5-(4-octylphenyl)pent-2-en-1-yl]-L-cysteine | 31.1% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-5-(4-pentylphenyl)pent-2-en-1-yl]-L-cysteine | 23.1% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-5-(4-propylphenyl)pent-2-en-1-yl]-L-cysteine | 20.7% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-7-(4-phenoxyphenoxy)hept-2-en-1-yl]-L-cysteine | 19.4% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-3-methyl-7-[(naphthalen-2-ylamino)oxy]hept-2-en-1-yl]-L-cysteine | 22.4% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-4-(4-benzylphenoxy)-3-methylbut-2-en-1-yl]-L-cysteine | 9.8% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2E)-5-(4-hexylphenyl)-3-methylpent-2-en-1-yl]-L-cysteine | 18.8% inhibition at 0.01 mM | Homo sapiens | |
N-acetyl-S-[(2Z)-4-(biphenyl-4-yl)-3-phenylbut-2-en-1-yl]-L-cysteine | 26.6% inhibition at 0.01 mM | Homo sapiens | |
N-[3-(phenylsulfonyl)propanoyl]-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | 22.7% inhibition at 0.01 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine methyl ester | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
isoprenylcysteine carboxyl methyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0194 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-phenoxybenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine | |
0.0346 | - |
pH and temperature not specified in the publication | Homo sapiens | N-acetyl-S-[(2E)-3-methyl-5-(4-octylphenyl)pent-2-en-1-yl]-L-cysteine |
General Information | Comment | Organism |
---|---|---|
physiological function | methylation of Ras by the enzyme is required for proper localization to the plasma membrane and downstream signaling | Homo sapiens |