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Literature summary for 2.1.1.100 extracted from
- Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase (2005), J. Biol. Chem., 280, 18790-18796.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-acetyl-S-farnesyl-L-cysteine | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme regulates Rac1 activity by controlling the interaction of Rac1 activity by controlling the interaction of Rac1 with Rho guanine nucleotide dissociation inhibitor, the enzyme regulates membrane accumulation and GTP loading of Rac1 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta endothelium | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme regulates Rac1 activity by controlling the interaction of Rac1 activity by controlling the interaction of Rac1 with Rho guanine nucleotide dissociation inhibitor, the enzyme regulates membrane accumulation and GTP loading of Rac1 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Icmt | - |
Homo sapiens |
| isoprenylcysteine carboxylmethyltransferase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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