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Literature summary for 2.1.1.100 extracted from

  • Hrycyna, C.A.; Sapperstein, S.K.; Clarke, S.; Michaelis, S.
    The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins (1991), EMBO J., 10, 1699-1709.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of TrpE-STE14 methyl transferase fusion protein in Escherichia coli Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Saccharomyces cerevisiae a-factor mating pheromone, Ras1 and Ras2 are putative substrates of the enzyme S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine ras-proteins Saccharomyces cerevisiae S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
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S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine a-factor, Ras1 and Ras2 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
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S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine a-factor mating pheromone, Ras1 and Ras2 are putative substrates of the enzyme Saccharomyces cerevisiae S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
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S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
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 Saccharomyces cerevisiae S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
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