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Literature summary for 2.1.1.1 extracted from

  • You, Z.; Liu, Y.; Liu, X.
    Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1 (2018), Oncol. Lett., 15, 9195-9201 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer. The overexpression of NNMT enhances PC-3 cell viability, invasion and migration capacity. The overexpression of NNMT significantly increases the mRNA level of sirtuin 1 in PC-3 cells. Nicotinamide treatment significantly suppresses the expression of SIRT1 even in PC-3 cells transfected with adeno-associated virus-NNMT Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P40261
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-

Source Tissue

Source Tissue Comment Organism Textmining
blood
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 Homo sapiens
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PC-3 cell
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 Homo sapiens
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prostate cancer cell line
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer up

General Information

General Information Comment Organism
physiological function the expression level of NNMT is elevated in the peripheral blood and tissues of patients with prostate cancer. The overexpression of NNMT enhances PC-3 cell viability, invasion and migration capacity. The overexpression of NNMT significantly increases the mRNA level of sirtuin 1 in PC-3 cells. Nicotinamide treatment significantly suppresses the expression of SIRT1 even in PC-3 cells transfected with adeno-associated virus-NNMT Homo sapiens