Literature summary for 2.1.1.1 extracted from

Thomas, M.G.; Sartini, D.; Emanuelli, M.; van Haren, M.J.; Martin, N.I.; Mountford, D.M.; Barlow, D.J.; Klamt, F.; Ramsden, D.B.; Reza, M.; Parsons, R.B.
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous beta-carboline norharman evidence for a novel detoxification pathway (2016), Biochem. J., 473, 3253-3267 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.09	-	norharman	pH 8.6, 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P40261	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Homo sapiens	-
SH-SY5Y cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + norharman + H+	-	Homo sapiens	S-adenosyl-L-homocysteine + 2-N-methylnorharman	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0004	-	norharman	pH 8.6, 37°C	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	cells expressing NMMT are less sensitive to beta-carbolines such as norharman	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.003	-	norharman	pH 8.6, 37°C	Homo sapiens

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Release 2023.1 (January 2023)