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Literature summary for 2.1.1.1 extracted from

  • Riederer, M.; Erwa, W.; Zimmermann, R.; Frank, S.; Zechner, R.
    Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine (2009), Atherosclerosis, 204, 412-417.
    View publication on PubMed
Search for more literature for 2.1.1.1

Activating Compound

Activating Compound Comment Organism Structure
additional information elevated enzyme activity during cell differentiation in adipose tissue Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-methylnicotinamide product inhibition Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Mus musculus
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 female and male C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell elevated enzyme activity during cell differentiation in adipose tissue Mus musculus
-
adipocyte
-
 Homo sapiens
-
adipocyte NNMT expression profile, overview Mus musculus
-
adipose tissue
-
 Homo sapiens
-
adipose tissue expression analysis, overview Mus musculus
-
embryonic fibroblast
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver expression analysis, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
NNMT
-
 Mus musculus
NNMT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Mus musculus
S-adenosyl-L-methionine
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is induced by nicotinic acid in adipose tissue up
Mus musculus the enzyme is induced by nicotinic acid in white adipose tissue, but chronic treatment does not cause hyperhomocysteinemia, overview up