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Literature summary for 2.1.1.1 extracted from

  • Aksoy, S.; Szumlanski, C.L.; Weinshilboum, R.M.
    Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization (1994), J. Biol. Chem., 269, 14835-14840.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N1-methylnicotinamide IC50 0.06 mM for human protein, 0.03 mM for recombinant protein Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
 S-adenosyl-L-methionine
-
 Homo sapiens
0.0022
-
 S-adenosyl-L-methionine recombinant protein Homo sapiens
0.38
-
 nicotinamide recombinant protein Homo sapiens
0.43
-
 nicotinamide
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 x * 29000, SDS-PAGE, recombinant protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Subunits

Subunits Comment Organism
? x * 29000, SDS-PAGE, recombinant protein Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.06
-
 IC50 0.06 mM for human protein, 0.03 mM for recombinant protein Homo sapiens N1-methylnicotinamide