Literature summary for 1.8.98.2 extracted from

Baek, J.Y.; Han, S.H.; Sung, S.H.; Lee, H.E.; Kim, Y.M.; Noh, Y.H.; Bae, S.H.; Rhee, S.G.; Chang, T.S.
Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2 (2012), J. Biol. Chem., 287, 81-89.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9D975	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Mus musculus	-
embryonic fibroblast	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	exposure of low steady-state levels ofH2O2 to A-549 or wild-type mouse embryonic fibroblast cells does not lead to any significant change in oxidative injury. Loss-of-function studies using sulfiredoxin-depleted A549 and sulfiredoxin -/- cells demonstrate a dramatic increase in extra- and intracellular H2O2, sulfinic 2-Cys peroxiredoxins, and apoptosis. Concomitant with hyperoxidation of mitochondrial peroxiredoxin Prx III, sulfiredoxin-depleted cells show an activation of mitochondria-mediated apoptotic pathways including mitochondria membrane potential collapse, cytochrome c release, and caspase activation	Mus musculus

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Release 2023.1 (January 2023)