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Literature summary for 1.8.98.2 extracted from

  • Park, J.W.; Mieyal, J.J.; Rhee, S.G.; Chock, P.B.
    Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin (2009), J. Biol. Chem., 284, 23364-23374.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.98.2

Cloned(Commentary)

Cloned (Comment) Organism
for expression in Escherichia coli BL21DE3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H100N Srx mutant Homo sapiens
R101M Srx mutant Homo sapiens
Y92R Srx mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Homo sapiens
-
 peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyzes the deglutathionylation of actin Homo sapiens ?
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
 Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Synonyms

Synonyms Comment Organism
Srx
-
 Homo sapiens
sulfiredoxin
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
glutathione
-
 Homo sapiens