BRENDA - Enzyme Database show
show all sequences of 1.8.98.2

A novel role for human sulfiredoxin in the reversal of glutathionylation

Findlay, V.J.; Townsend, D.M.; Morris, T.E.; Fraser, J.P.; He, L.; Tew, K.D.; Cancer Res. 66, 6800-6806 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in HEK293 cells and Escherichia coli
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
C99S
mutant created to show the importance of the cytosine residue in the deglutathionylation function of the protein
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9BYN0
-
-
Purification (Commentary)
Commentary
Organism
Ni2+-NTA column chromatography
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
668161
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in HEK293 cells and Escherichia coli
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
C99S
mutant created to show the importance of the cytosine residue in the deglutathionylation function of the protein
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
Ni2+-NTA column chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
668161
Homo sapiens
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
-
-
?
Other publictions for EC 1.8.98.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742457
Shi
Sulfiredoxin involved in the ...
Rattus norvegicus
Exp. Cell Res.
352
273-280
2017
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1
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742601
Calderon
Glutathionylation of pea chlo ...
Pisum sativum
Front. Plant Sci.
8
118
2017
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742566
Rhee
Mitochondrial H2O2 signaling ...
Mus musculus
Free Radic. Biol. Med.
99
120-127
2016
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742996
Sevilla
The thioredoxin/peroxiredoxin ...
Arabidopsis thaliana
J. Exp. Bot.
66
2945-2955
2015
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724192
Moon
Reversal of 2-Cys peroxiredoxi ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
432
291-295
2013
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1
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743135
Li
Sulfiredoxin-1 protects PC12 ...
Rattus norvegicus
J. Neurosci. Res.
91
861-870
2013
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1
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743228
Kil
Study of the signaling functi ...
Mus musculus
Methods Enzymol.
527
169-181
2013
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725015
Chi
Dual functions of Arabidopsis ...
Arabidopsis thaliana
FEBS Lett.
586
3493-3499
2012
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725510
Baek
Sulfiredoxin protein is critic ...
Mus musculus
J. Biol. Chem.
287
81-89
2012
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725010
Roussel
The rate-limiting step of sulf ...
Saccharomyces cerevisiae
FEBS Lett.
585
574-578
2011
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726220
Iglesias-Baena
The dual-targeted plant sulfir ...
Arabidopsis thaliana, Pisum sativum
Plant Physiol.
155
944-955
2011
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5
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712607
Iglesias-Baena
Characterization of plant sulf ...
Arabidopsis thaliana, Arabidopsis thaliana Columbia
J. Exp. Bot.
61
1509-1521
2010
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6
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695553
Kim
A colorimetric assay for sulfi ...
Homo sapiens
Anal. Biochem.
393
36-40
2009
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1
1
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698052
Singh
Nrf2-dependent sulfiredoxin-1 ...
Homo sapiens, Mus musculus
Free Radic. Biol. Med.
46
376-386
2009
-
2
1
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2
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2
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4
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4
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1
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4
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2
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4
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4
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698928
Park
Deglutathionylation of 2-Cys p ...
Homo sapiens
J. Biol. Chem.
284
23364-23374
2009
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1
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3
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1
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1
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1
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1
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1
2
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698953
Roussel
The catalytic mechanism of Sul ...
Saccharomyces cerevisiae
J. Biol. Chem.
284
33048-33055
2009
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1
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3
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698993
Noh
Sulfiredoxin Translocation int ...
Homo sapiens
J. Biol. Chem.
284
8470-8477
2009
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1
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2
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687747
Roussel
Evidence for the formation of ...
Saccharomyces cerevisiae
J. Biol. Chem.
283
22371-22382
2008
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687749
Joensson
Identification of intact prote ...
Homo sapiens
J. Biol. Chem.
283
22890-22894
2008
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688522
Soriano
Induction of sulfiredoxin expr ...
Rattus norvegicus
J. Neurochem.
107
533-543
2008
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689157
Joensson
Structure of the sulphiredoxin ...
Homo sapiens
Nature
451
98-101
2008
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700520
Lei
Protein cysteine sulfinic acid ...
Homo sapiens
Oncogene
27
4877-4887
2008
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1
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670564
Rey
The Arabidopsis thaliana sulfi ...
Arabidopsis thaliana
Plant J.
49
505-514
2007
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667711
Lee
Mutagenesis and modeling of th ...
Homo sapiens
Biochemistry
45
15301-15309
2006
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668161
Findlay
A novel role for human sulfire ...
Homo sapiens
Cancer Res.
66
6800-6806
2006
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1
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668202
Liu
Molecular and functional chara ...
Arabidopsis thaliana, Oryza sativa
Cell Res.
16
287-296
2006
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2
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2
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