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Literature summary for 1.8.98.2 extracted from

  • Woo, H.A.; Jeong, W.; Chang, T.S.; Park, K.J.; Park, S.J.; Yang, J.S.; Rhee, S.G.
    Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-Cys peroxiredoxins (2005), J. Biol. Chem., 280, 3125-3128.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Rattus norvegicus reduction of Cys-SO2H by Srx is specific to 2-Cys peroxiredoxin isoforms. For proteins such as Prx VI and GAPDH, sulfinic acid formation might be an irreversible process that causes protein damage peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
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Rattus norvegicus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
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?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH reduction of Cys-SO2H by Srx is specific to 2-Cys peroxiredoxin isoforms. For proteins such as Prx VI and GAPDH, sulfinic acid formation might be an irreversible process that causes protein damage Rattus norvegicus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?