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Literature summary for 1.8.4.2 extracted from

  • Garcin, E.B.; Bornet, O.; Elantak, L.; Vita, N.; Pieulle, L.; Guerlesquin, F.; Sebban-Kreuzer, C.
    Structural and mechanistic insights into unusual thiol disulfide oxidoreductase (2012), J. Biol. Chem., 287, 1688-1697.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli TG1 and Rosetta-gami cells Desulfovibrio vulgaris

Protein Variants

Protein Variants Comment Organism
H33G the mutant shows a loss of the capacity of the protein to isomerize, or shuffle, incorrect disulfides of scrambled RNase A yielding 10% active RNase A only Desulfovibrio vulgaris

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Desulfovibrio vulgaris 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GSH + protein-disulfide Desulfovibrio vulgaris
-
 GSSG + protein-dithiol
-
 ?

Organism

Organism UniProt Comment Textmining
Desulfovibrio vulgaris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-nitrilotriacetic acid column chromatography Desulfovibrio vulgaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSH + 5,5'-dithiobis(nitrobenzoic acid)
-
 Desulfovibrio vulgaris ?
-
 ?
GSH + protein-disulfide
-
 Desulfovibrio vulgaris GSSG + protein-dithiol
-
 ?
additional information the enzyme is unable to reduce insulin Desulfovibrio vulgaris ?
-
 ?

Synonyms

Synonyms Comment Organism
desulfothioredoxin
-
 Desulfovibrio vulgaris
Dtrx
-
 Desulfovibrio vulgaris
TDOR
-
 Desulfovibrio vulgaris
thiol disulfide oxidoreductase
-
 Desulfovibrio vulgaris