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Literature summary for 1.8.4.2 extracted from
- Insulin degradation in insulinoma: evidence for the occurrence of an inactive form of glutathione-insulin transhydrogenase and for the absence of insulin A and B chains degrading protease(s) (1974), Biochem. Biophys. Res. Commun., 60, 1119-1126.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | 0.0078 | Insulin | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| insulinoma cell | glutathione-insulin transhydrogenase is present in an inactive state as a divalent metal ion complex that can be activated by EDTA and/or GSH | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + insulin | - |
Homo sapiens | GSSG + reduced insulin chain A and B | - |
? |  |
| GSH + protein disulfide | - |
Homo sapiens | GSSG + protein-dithiol | - |
? | |
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Release 2023.1 (January 2023)
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