Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.4.2 extracted from

  • Spolter, P.D.; Vogel, J.M.
    Rat-liver thiol: protein-disulphide oxidoreductase (1968), Biochim. Biophys. Acta, 167, 525-537.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
EDTA 5 mM: inhibition Rattus norvegicus

General Stability

General Stability Organism
EDTA 5mM, 37°C, phosphate buffer, total loss of activity within 30-60 min, can partially be prevented by NADPH Rattus norvegicus
metal ions required for activity and maintenance of the proper conformation of the enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cysteine at high concentration Rattus norvegicus
EDTA 50% inhibition at 5 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus
0.13
-
reduced dithiothreitol
-
Rattus norvegicus
0.14
-
dihydrolipoamide
-
Rattus norvegicus
0.2
-
2-mercaptoethanol
-
Rattus norvegicus
0.2
-
dihydrolipoate
-
Rattus norvegicus
0.27
-
cysteine
-
Rattus norvegicus
0.31
-
GSH
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cs+ 0.3 M: activates Rattus norvegicus
Mn2+ 1 mM: activates Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-mercaptoethanol + protein disulfide
-
Rattus norvegicus 2-mercaptoethanol disulfide + protein-dithiol
-
?
dihydrolipoamide + protein disulfide
-
Rattus norvegicus ?
-
?
dihydrolipoate + protein disulfide
-
Rattus norvegicus ?
-
?
dithiothreitol + protein disulfide
-
Rattus norvegicus ?
-
?
GSH + protein disulfide
-
Rattus norvegicus GSSG + protein-dithiol
-
?
L-cysteine + protein disulfide
-
Rattus norvegicus cystine + protein-dithiol
-
?
reduced dithiothreitol + NADP+
-
Rattus norvegicus oxidized dithiothreitol + NADPH + H+
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
phosphate buffer, 5 h without loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
GSH Rattus norvegicus
9
-
DL-dihydrolipoate Rattus norvegicus