Any feedback?
Literature summary for 1.8.4.2 extracted from
- Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase) (1988), Biochim. Biophys. Acta, 949, 169-180.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylethanolamine | activates at low concentration | Homo sapiens |  |
| phosphatidylethanolamine | activates at low concentration | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence | Homo sapiens |
| characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | Homo sapiens | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Rattus norvegicus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + insulin | - |
Homo sapiens | GSSG + reduced insulin chain A and B | - |
? | |
| GSH + protein disulfide | - |
Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Homo sapiens | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | feedback control via insulin in the liver | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GIT | - |
Homo sapiens |
| GIT | - |
Rattus norvegicus |
| More | - |
Rattus norvegicus |
| More | protein-disulfide isomerase EC 5.3.4.1 and protein-disulfide oxidoreductase EC 1.8.4.2 are identical and form the glutathione-insulin transhydrogenase | Homo sapiens |
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