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Literature summary for 1.8.4.12 extracted from

  • Cao, Z.; Mitchell, L.; Hsia, O.; Scarpa, M.; Caldwell, S.T.; Alfred, A.D.; Gennaris, A.; Collet, J.F.; Hartley, R.C.; Bulleid, N.J.
    Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase (2018), Biochem. J., 475, 827-838.
    View publication on PubMed
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as a fusion protein with GST which is subsequently cleaved after purification Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum two splice variants of the enzyme (Msr B3) that differ in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria Homo sapiens 5783
-
mitochondrion two splice variants of the enzyme (Msr B3) that differ in their N-terminal signal sequence, which directs the protein to either the endoplasmic reticulum (ER) or mitochondria Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IXL7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information stereospecificity towards R-methionine sulfoxide Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme (MsrB3) is able to function in vivo to complement a bacterial strain deficient in endogenous Msr Homo sapiens