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Literature summary for 1.8.4.12 extracted from
- Structure and electron-transfer pathway of the human methionine sulfoxide reductase MsrB3 (2020), Antioxid. Redox Signal., 33, 665-678 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in in Escherichia coli as a fusion with maltose binding protein | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop vapor diffusion method, crystals diffracting to 1.87 A resolution, the MsrB3 structure is determined by using X-ray crystallography | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8IXL7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide-L-methionine + thioredoxin disulfide + H2O | the study reveals a mechanism to shuttle oxidizing equivalents from the primary MsrB3 active site toward the enzyme surface, where they would be available for further dithiol-disulfide exchange reactions | Homo sapiens | peptide-L-methionine (R)-S-oxide + thioredoxin | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrB3 | - |
Homo sapiens |
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