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Literature summary for 1.8.4.12 extracted from

  • Lim, D.H.; Han, J.Y.; Kim, J.R.; Lee, Y.S.; Kim, H.Y.
    Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila (2012), Biochem. Biophys. Res. Commun., 419, 20-26.
    View publication on PubMed
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Drosophila melanogaster Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine (R)-sulfoxide + dithiothreitol
-
 Homo sapiens dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B
-
 Homo sapiens
MsrB
-
 Homo sapiens
MsrB3A isoform Homo sapiens

General Information

General Information Comment Organism
physiological function neuronal expression of isoform MsrB3A renders Drosophilaflies resistant to oxidative stress. These flies also show significantly enhanced cold (4°C) and heat (37°C) tolerance. Expression of isoform MsrB3A in the whole body and nervous system extends the lifespan of fruit flies at 29°C by 43-50% and 12-37%, respectively. Additionally, isoform MsrB3A overexpression significantly delays the age-related decline in locomotor activity and fecundity Homo sapiens