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Literature summary for 1.8.4.12 extracted from

  • Schallreuter, K.U.; Rubsam, K.; Chavan, B.; Zothner, C.; Gillbro, J.M.; Spencer, J.D.; Wood, J.M.
    Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus (2006), Biochem. Biophys. Res. Commun., 342, 145-152.
    View publication on PubMed
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis in subcellular fractions of melanocytes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine-(R)-S-oxide + thioredoxin Homo sapiens MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin L-methionine + thioredoxin disulfide + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 several splicing variants resulting in three isozymes MsrB1-3
-

Purification (Commentary)

Purification (Comment) Organism
partially by subcellular fractionation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
melanocyte epidermal Homo sapiens
-
additional information expression analysis of MsrB isozymes Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(R)-S-oxide + thioredoxin MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 r
L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction, MsrB accepts free and protein-bound substrates Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 r

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B
-
 Homo sapiens
MsrB
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Homo sapiens